CDH23

Across TCGA patient cohorts, CDH23 mutation is significantly associated with the total protein of many other genes, with 88 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH23-associated genes across cancer lineages are Rad50, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with CDH23 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDH23-to-partner and partner-to-CDH23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by CDH23-low versus CDH23-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH23→partner) and Y-score (partner→CDH23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Rad50 →	-0.250	-2.000	<.001	.007	3	5
COAD	Caspase-7-cleavedD198 →	+0.963	+2.264	<.001	<.001	3	5
UCEC	4E-BP1 →	+0.235	+1.241	<.001	<.001	3	4
UCEC	PCNA →	+0.144	+0.884	.002	.007	3	4
STAD	eEF2 →	+0.218	+1.999	.042	.009	3	3
STAD	FASN →	+0.376	+2.131	.010	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

Rad50 by CDH23 expression — COAD

Explore this box plot interactively →