CDH23

Across TCGA cell cohorts, CDH23 mutation is significantly associated with the RNA expression of many other genes, with 2,803 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CDH23-associated genes across cancer lineages are OR2A5, CNOT6, and ZNF484. Each is linked with CDH23 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDH23-to-partner and partner-to-CDH23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2A5 grouped by CDH23-low versus CDH23-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH23→partner) and Y-score (partner→CDH23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OR2A5 →	+0.035	+4.201	<.001	.001	3	3
BLOOD_Leukemia	CNOT6 →	+0.518	+2.252	.002	.003	3	3
LARGE_INTESTINE	ZNF484 →	+0.362	+2.541	<.001	.001	3	3
BLOOD_Leukemia	QRICH2 →	+0.679	+2.252	.002	.003	3	3
BLOOD_Leukemia	CARD6 →	-1.077	-2.584	<.001	.005	3	3
BLOOD_Leukemia	KATNBL1 →	+0.387	+2.252	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,803 associations by consensus.

OR2A5 by CDH23 expression — KIDNEY

Explore this box plot interactively →