CDH20

Across TCGA cell cohorts, CDH20 mutation is significantly associated with the RNA expression of many other genes, with 522 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDH20-associated genes across cancer lineages are PSMG2, SYCE3, and RPP21. Each is linked with CDH20 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDH20-to-partner and partner-to-CDH20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMG2 grouped by CDH20-low versus CDH20-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH20→partner) and Y-score (partner→CDH20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PSMG2 →	+0.583	+3.451	<.001	.002	3	2
LARGE_INTESTINE	SYCE3 →	+0.799	+3.364	<.001	.002	3	2
LARGE_INTESTINE	RPP21 →	+0.537	+3.301	<.001	.003	3	2
LARGE_INTESTINE	ZNF487 →	+0.790	+3.234	<.001	.004	3	2
LARGE_INTESTINE	TFB1M →	+0.635	+3.364	<.001	.002	3	2
BREAST	REG1B →	+0.395	+3.432	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 522 associations by consensus.

PSMG2 by CDH20 expression — LARGE_INTESTINE

Explore this box plot interactively →