CDH19

Across TCGA patient cohorts, CDH19 mutation is significantly associated with the RNA expression of many other genes, with 3,758 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH19-associated genes across cancer lineages are RBFA, NDUFA9, and EIF5A. Each is linked with CDH19 in more than 5 cancer types. Because this analysis shows association rather than direction, both CDH19-to-partner and partner-to-CDH19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBFA grouped by CDH19-low versus CDH19-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH19→partner) and Y-score (partner→CDH19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RBFA →	+0.394	+3.229	.002	.008	3	5
LUAD	NDUFA9 →	+0.337	+2.629	.007	.005	3	5
UCEC	EIF5A →	+0.212	+1.450	.009	<.001	3	5
UCEC	TACC3 →	+0.452	+1.725	<.001	<.001	3	5
COAD	PIMREG →	+0.690	+2.700	<.001	.006	1	6
COAD	PSRC1 →	+0.538	+3.479	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,758 associations by consensus.

RBFA by CDH19 expression — LUSC

Explore this box plot interactively →