CDH19

Across TCGA pan-cancer cohorts, CDH19 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CDH19’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CDH19 RNA is repressed in tumor relative to normal tissue. In most cancer types CDH19 is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and LUAD are the cancer types where CDH19 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDH19 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−1.831	<.001	12	view →
BLCA	Male	All	−1.942	<.001	11	view →
LUAD	All	III,IV	−1.066	<.001	9	view →
THCA	Female	III,IV	−0.596	<.001	9	view →
KIRC	All	II,III,IV	−0.374	<.001	9	view →
LUSC	Female	All	−0.960	<.001	8	view →
LIHC	Male	All	−0.848	<.001	8	view →
STAD	All	All	−1.359	<.001	7	view →
BRCA	All	III,IV	−0.805	<.001	6	view →
UCEC	All	All	−0.710	<.001	6	view →
READ	All	All	−2.372	<.001	5	view →
HNSC	All	II,III,IV	−0.514	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CDH19–COAD

Open the COAD breakdown →