CDH19

Across TCGA patient cohorts, CDH19 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH19-associated genes across cancer lineages are Cyclin-E2, PTEN, and Chk1. Each is linked with CDH19 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDH19-to-partner and partner-to-CDH19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by CDH19-low versus CDH19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH19→partner) and Y-score (partner→CDH19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.094	+1.047	.036	.018	3	4
LUAD	PTEN →	-0.258	-3.321	.019	.009	3	3
HNSC	Chk1 →	+0.291	+3.321	.026	.009	3	2
COAD	Caspase-7-cleavedD198 →	+1.549	+3.330	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.187	-1.473	.005	.005	3	2
UCEC	A-Raf_pS299 →	-0.105	-1.192	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Cyclin-E2 by CDH19 expression — UCEC

Explore this box plot interactively →