CDH19

Across TCGA cell cohorts, CDH19 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDH19-associated genes across cancer lineages are ACER1, SLC32A1, and OR1L6. Each is linked with CDH19 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDH19-to-partner and partner-to-CDH19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by CDH19-low versus CDH19-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH19→partner) and Y-score (partner→CDH19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ACER1 →	+0.099	+4.044	<.001	.009	3	2
BLOOD_Leukemia	SLC32A1 →	+0.715	+4.223	<.001	.001	3	2
LUNG_NSCLC_LUAD	OR1L6 →	+0.011	+4.078	<.001	.009	3	2
SOFT_TISSUE	FOXI2 →	+0.006	+4.930	<.001	.008	3	1
LUNG_SCLC	WFDC10B →	+0.102	+4.269	<.001	.005	3	1
LUNG_SCLC	SPANXN5 →	+0.089	+4.269	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

ACER1 by CDH19 expression — LUNG_SCLC

Explore this box plot interactively →