CDH18

Across TCGA patient cohorts, CDH18 mutation is significantly associated with the RNA expression of many other genes, with 6,276 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH18-associated genes across cancer lineages are DLGAP5, MZT1, and EXOSC8. Each is linked with CDH18 in more than 5 cancer types. Because this analysis shows association rather than direction, both CDH18-to-partner and partner-to-CDH18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DLGAP5 grouped by CDH18-low versus CDH18-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH18→partner) and Y-score (partner→CDH18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DLGAP5 →	+0.676	+3.011	.002	<.001	3	6
STAD	MZT1 →	+0.651	+3.712	<.001	<.001	3	5
UCEC	EXOSC8 →	+0.331	+1.673	.001	.006	3	5
STAD	ACYP1 →	+0.544	+2.857	.001	.001	3	5
LUAD	UBE2T →	+0.750	+1.904	<.001	<.001	3	5
LUAD	POLE2 →	+0.506	+2.234	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,276 associations by consensus.

DLGAP5 by CDH18 expression — LUAD

Explore this box plot interactively →