CDH18

Across TCGA cell cohorts, CDH18 mutation is significantly associated with the RNA expression of many other genes, with 761 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDH18-associated genes across cancer lineages are FAM118A, FIG4, and NIPSNAP1. Each is linked with CDH18 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDH18-to-partner and partner-to-CDH18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM118A grouped by CDH18-low versus CDH18-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH18→partner) and Y-score (partner→CDH18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM118A →	+0.894	+2.459	.004	.006	3	2
SKIN	FIG4 →	+0.687	+2.829	<.001	<.001	3	2
SKIN	NIPSNAP1 →	+0.617	+2.043	.003	.008	3	2
LUNG_SCLC	GOLGA6L1 →	+0.020	+2.256	<.001	.008	3	2
LARGE_INTESTINE	GGA1 →	+0.559	+3.169	.003	.006	3	2
LARGE_INTESTINE	DNTTIP1 →	-0.689	-3.321	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 761 associations by consensus.

FAM118A by CDH18 expression — LARGE_INTESTINE

Explore this box plot interactively →