CDH15

Across TCGA cell cohorts, CDH15 mutation is significantly associated with the RNA expression of many other genes, with 198 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDH15-associated genes across cancer lineages are DPRX, CT45A6, and VCY. Each is linked with CDH15 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDH15-to-partner and partner-to-CDH15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by CDH15-low versus CDH15-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH15→partner) and Y-score (partner→CDH15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DPRX →	+0.109	+5.060	<.001	.001	3	2
OESOPHAGUS	CT45A6 →	+0.099	+4.906	<.001	.006	3	1
OVARY	VCY →	+0.197	+3.643	<.001	.002	3	1
OVARY	OR10A5 →	+0.022	+3.444	<.001	.003	3	1
OVARY	KRT24 →	+0.561	+3.473	<.001	.008	3	1
LARGE_INTESTINE	PSMD9 →	+0.502	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 198 associations by consensus.

DPRX by CDH15 expression — BLOOD_Leukemia

Explore this box plot interactively →