CDH15

Across TCGA pan-cancer cohorts, CDH15 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CDH15 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CDH15 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDH15 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LGG show a favorable association.

KIRC, ACC, and LUAD are the cancer types where CDH15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.552	0.700	<.001	97	view →
ACC	DFS	Tertile	All	0.242	0.606	.002	41	view →
LUAD	OS	Quartile	All	0.855	0.748	.003	35	view →
KIRP	DFS	Quartile	All	0.767	0.919	.003	31	view →
CESC	DFS	Median	III,IV	0.440	0.781	.001	28	view →
HNSC	OS	Median	All	0.704	0.796	.003	27	view →
LUSC	DFS	Tertile	All	0.683	0.790	.004	27	view →
LGG	OS	Median	All	0.936	0.852	<.001	22	view →
UCS	DFS	Quartile	II,III,IV	0.690	0.157	.004	20	view →
STAD	OS	Tertile	II,III,IV	0.370	0.678	.012	18	view →
PRAD	DFS	Median	All	0.843	0.924	.003	18	view →
COAD	DFS	Median	II,III,IV	0.396	0.657	.010	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CDH15–KIRC (DFS)

Open the KIRC breakdown →