CDH1

Across TCGA cell cohorts, CDH1 mutation is significantly associated with the RNA expression of many other genes, with 242 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDH1-associated genes across cancer lineages are TEX53, RNPEP, and ARMC7. Each is linked with CDH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDH1-to-partner and partner-to-CDH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX53 grouped by CDH1-low versus CDH1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH1→partner) and Y-score (partner→CDH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TEX53 →	+0.142	+3.807	<.001	.003	3	2
LARGE_INTESTINE	RNPEP →	+0.713	+3.212	.001	.006	3	2
STOMACH	ARMC7 →	+0.615	+1.944	.002	.008	3	2
STOMACH	PMM2 →	+0.525	+2.085	.007	.007	3	2
STOMACH	CAPN13 →	+0.754	+2.655	.004	<.001	3	2
STOMACH	TMEM144 →	+0.891	+2.655	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 242 associations by consensus.

TEX53 by CDH1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →