CDCA8

Across TCGA patient cohorts, CDCA8 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDCA8-associated genes across cancer lineages are 14-3-3_beta, IGFBP2, and JNK_pT183_Y185. Each is linked with CDCA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDCA8-to-partner and partner-to-CDCA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CDCA8-low versus CDCA8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDCA8→partner) and Y-score (partner→CDCA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.100	-2.973	.033	.035	3	1
UCEC	IGFBP2 →	-0.723	-3.000	.016	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.208	-3.169	.008	.019	3	1
UCEC	JNK2 →	+0.245	+2.584	.008	.011	3	1
UCEC	Ku80 →	+0.296	+1.887	.007	.031	3	1
UCEC	PDK1_pS241 →	+0.250	+2.196	.001	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

14-3-3_beta by CDCA8 expression — UCEC

Explore this box plot interactively →