CDCA8

Across TCGA pan-cancer cohorts, CDCA8 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of CDCA8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CDCA8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CDCA8 is over-expressed in tumor.

HNSC, COAD, and BLCA are the cancer types where CDCA8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDCA8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+2.157	<.001	12	view →
COAD	Female	III,IV	+1.498	<.001	12	view →
BLCA	Male	III,IV	+3.421	<.001	11	view →
KIRP	All	IV	+2.912	<.001	11	view →
KIRC	Male	IV	+1.472	<.001	11	view →
LUAD	Male	III,IV	+3.496	<.001	9	view →
STAD	All	II,III,IV	+2.557	<.001	9	view →
LIHC	Male	All	+2.338	<.001	9	view →
UCEC	All	III,IV	+4.202	<.001	8	view →
LUSC	Female	All	+4.087	<.001	8	view →
BRCA	All	III,IV	+2.527	<.001	6	view →
CHOL	Male	All	+4.071	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

CDCA8–HNSC

Open the HNSC breakdown →