CDCA4

Across TCGA pan-cancer cohorts, CDCA4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CDCA4 data layer compared with 29 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher CDCA4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDCA4 expression acts as an unfavorable survival marker.

CESC, ACC, and BLCA are the cancer types where CDCA4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.183	0.743	<.001	48	view →
ACC	DFS	Median	All	0.010	0.667	<.001	45	view →
BLCA	OS	Median	III,IV	0.197	0.684	.013	18	view →
LUSC	OS	Median	All	0.215	0.676	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CDCA4–CESC (DFS)

Open the CESC breakdown →