CDC6

Across TCGA patient cohorts, CDC6 protein abundance is significantly associated with the RNA expression of many other genes, with 739 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CDC6-associated genes across cancer lineages are SEC14L2, FKBP3, and COCH. Each is linked with CDC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC6-to-partner and partner-to-CDC6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDC6 versus SEC14L2 in BRCA, with a Pearson correlation of -0.79.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC6→partner) and Y-score (partner→CDC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEC14L2 →	-2.737	-1.372	.001	.008	3	1
BRCA	FKBP3 →	-0.842	-1.054	.006	<.001	3	1
BRCA	COCH →	+1.924	+1.304	.004	.009	3	1
BRCA	CGRRF1 →	-0.886	-1.004	.005	.002	3	1
BRCA	PPM1A →	-1.202	-1.115	.004	.005	3	1
BRCA	MTHFD1 →	-0.495	-0.863	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 739 associations by consensus.

CDC6 vs SEC14L2 — BRCA

Explore this scatter interactively →