CDC6

Across TCGA patient cohorts, CDC6 mutation is significantly associated with the RNA expression of many other genes, with 1,496 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC6-associated genes across cancer lineages are RNU6-338P, RN7SL134P, and MIR3915. Each is linked with CDC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC6-to-partner and partner-to-CDC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-338P grouped by CDC6-low versus CDC6-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC6→partner) and Y-score (partner→CDC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-338P →	+0.236	+4.051	<.001	.001	3	2
UCEC	RN7SL134P →	+0.177	+2.947	<.001	<.001	3	2
UCEC	MIR3915 →	+0.150	+3.736	.002	.009	3	2
UCEC	PMPCA →	+0.377	+3.032	.006	<.001	3	2
LUSC	RNA5SP396 →	+0.085	+4.295	<.001	.006	3	2
LUSC	SNORD82 →	+0.455	+3.862	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,496 associations by consensus.

RNU6-338P by CDC6 expression — BLCA

Explore this box plot interactively →