CDC5L

Across TCGA pan-cancer cohorts, CDC5L Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CDC5L data layer compared with 25 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CDC5L Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated CDC5L expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where CDC5L Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.825	0.629	.001	36	view →
HNSC	OS	Median	All	0.156	0.710	.002	24	view →
LUAD	OS	Median	All	0.354	0.688	.004	21	view →
ESCA	DFS	Median	II,III,IV	0.023	0.523	<.001	12	view →
BLCA	OS	Median	III,IV	0.192	0.686	<.001	12	view →
LUSC	OS	Median	II,III,IV	0.170	0.629	.041	3	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CDC5L–UCEC (DFS)

Open the UCEC breakdown →