CDC5L

Across TCGA pan-cancer cohorts, CDC5L RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CDC5L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CDC5L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CDC5L is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where CDC5L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDC5L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.620	<.001	12	view →
LIHC	Male	All	+0.895	<.001	9	view →
THCA	All	All	−0.321	.001	8	view →
KICH	Female	All	−1.303	<.001	7	view →
CHOL	Male	All	+1.348	<.001	5	view →
LUAD	Male	All	+0.500	<.001	5	view →
LUSC	All	All	+0.439	<.001	5	view →
STAD	All	II,III,IV	+0.654	<.001	4	view →
KIRC	All	All	+0.237	.003	4	view →
BRCA	All	All	+0.195	.001	4	view →
ESCA	Female	All	+0.689	.024	2	view →
COAD	Male	All	+0.390	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CDC5L–HNSC

Open the HNSC breakdown →