CDC5L

Across TCGA pan-cancer cohorts, CDC5L mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CDC5L data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CDC5L mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CDC5L expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

HNSC, COAD, and PDAC are the cancer types where CDC5L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.760	0.929	.001	74	view →
COAD	DFS	Median	All	1.000	0.920	.014	48	view →
PDAC	OS	Median	IV	0.951	0.381	.006	6	view →
OV	DFS	Median	All	0.848	1.000	.017	4	view →
LSCC	OS	Quartile	All	0.903	0.688	.036	4	view →
LUAD	DFS	Median	All	0.966	0.839	.020	3	view →
CCRCC	DFS	Median	II,III,IV	0.726	0.491	.027	3	view →
GBM	OS	Quartile	All	0.515	0.322	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CDC5L–HNSC (OS)

Open the HNSC breakdown →