CDC5L

Across TCGA patient cohorts, CDC5L protein abundance is significantly associated with the RNA expression of many other genes, with 19,520 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CDC5L-associated genes across cancer lineages are POLR1C, HDAC2, and VRK1. Each is linked with CDC5L in more than 7 cancer types. Because this analysis shows association rather than direction, both CDC5L-to-partner and partner-to-CDC5L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDC5L versus POLR1C in LSCC, with a Pearson correlation of 0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC5L→partner) and Y-score (partner→CDC5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	POLR1C →	+0.661	+0.285	<.001	<.001	3	8
UCEC	HDAC2 →	+0.596	+0.163	<.001	<.001	3	8
HNSC	VRK1 →	+0.646	+0.102	.001	.004	3	7
HNSC	NELFCD →	+0.658	+0.149	.007	.007	2	8
LSCC	TMEM97 →	+0.983	+0.250	<.001	<.001	3	7
HNSC	FANCE →	+0.842	+0.131	.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,520 associations by consensus.

CDC5L vs POLR1C — LSCC

Explore this scatter interactively →