CDC5L

Across TCGA patient cohorts, CDC5L mutation is significantly associated with the RNA expression of many other genes, with 3,647 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC5L-associated genes across cancer lineages are RNU4-61P, DPPA5P1, and PPIAP5. Each is linked with CDC5L in more than 2 cancer types. Because this analysis shows association rather than direction, both CDC5L-to-partner and partner-to-CDC5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-61P grouped by CDC5L-low versus CDC5L-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC5L→partner) and Y-score (partner→CDC5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNU4-61P →	+0.704	+3.126	<.001	.007	3	3
SKCM	DPPA5P1 →	+0.121	+2.894	<.001	.006	3	3
CESC	PPIAP5 →	+0.101	+4.127	<.001	.003	3	2
BLCA	NPM1P2 →	+0.049	+3.758	.001	.008	3	2
BLCA	APONP →	+0.062	+4.314	.001	.009	3	2
KIRP	PSAT1P2 →	+0.046	+5.376	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,647 associations by consensus.

RNU4-61P by CDC5L expression — STAD

Explore this box plot interactively →