CDC5L

Across TCGA patient cohorts, CDC5L mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC5L-associated genes across cancer lineages are FoxM1, JNK_pT183_Y185, and Notch1. Each is linked with CDC5L in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC5L-to-partner and partner-to-CDC5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by CDC5L-low versus CDC5L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC5L→partner) and Y-score (partner→CDC5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.196	+1.473	.013	.006	3	2
UCEC	JNK_pT183_Y185 →	-0.169	-2.502	.001	.001	3	2
UCEC	Notch1 →	+0.147	+1.372	<.001	.022	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.494	-2.392	<.001	<.001	3	2
UCEC	PCNA →	+0.256	+2.137	<.001	<.001	3	2
UCEC	Src_pY527 →	-0.303	-1.668	.021	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

FoxM1 by CDC5L expression — UCEC

Explore this box plot interactively →