CDC5L

Across TCGA cell cohorts, CDC5L mutation is significantly associated with the RNA expression of many other genes, with 188 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDC5L-associated genes across cancer lineages are OR11H6, HELT, and ZNF705G. Each is linked with CDC5L in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC5L-to-partner and partner-to-CDC5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H6 grouped by CDC5L-low versus CDC5L-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC5L→partner) and Y-score (partner→CDC5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR11H6 →	+0.026	+4.321	<.001	.009	3	1
CNS	HELT →	+0.040	+4.321	<.001	.009	3	1
CNS	ZNF705G →	+0.011	+4.315	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR10R2 →	+0.019	+5.472	<.001	<.001	3	1
LARGE_INTESTINE	AXIN1 →	+0.748	+3.364	<.001	.002	3	1
LARGE_INTESTINE	MTFMT →	+0.601	+3.364	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 188 associations by consensus.

OR11H6 by CDC5L expression — CNS

Explore this box plot interactively →