CDC5L

Across TCGA cell cohorts, CDC5L mutation is significantly associated with the mutation status of many other genes, with 4,158 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDC5L-associated genes across cancer lineages are RAPGEF1, TBX2, and RNF2. Each is linked with CDC5L in more than 3 cancer types. Because this analysis shows association rather than direction, both CDC5L-to-partner and partner-to-CDC5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAPGEF1 grouped by CDC5L-low versus CDC5L-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC5L→partner) and Y-score (partner→CDC5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RAPGEF1 →	+5.392	+5.392	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	TBX2 →	+5.392	+5.392	.004	.004	1	4
CNS	RNF2 →	+6.199	+6.199	<.001	<.001	1	4
CNS	SF3B3 →	+5.614	+5.044	.003	.003	1	4
CNS	GSPT2 →	+5.614	+5.044	.003	.003	1	4
LARGE_INTESTINE	SH2D3C →	+2.182	+2.754	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,158 associations by consensus.

RAPGEF1 by CDC5L expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →