CDC45

Across TCGA patient cohorts, CDC45 protein abundance is significantly associated with the RNA expression of many other genes, with 8,638 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CDC45-associated genes across cancer lineages are CDKN3, NCAPG, and CDCA3. Each is linked with CDC45 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDC45-to-partner and partner-to-CDC45 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDC45 versus CDKN3 in LUAD, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC45→partner) and Y-score (partner→CDC45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDKN3 →	+1.304	+0.550	.002	.003	3	3
LUAD	NCAPG →	+2.245	+0.896	<.001	.005	3	3
LUAD	CDCA3 →	+2.242	+0.958	<.001	.002	3	3
LSCC	TTK →	+1.266	+0.751	.001	<.001	3	3
UCEC	CENPA →	+2.114	+1.026	.001	.008	3	3
UCEC	CDC20 →	+2.345	+0.818	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,638 associations by consensus.

CDC45 vs CDKN3 — LUAD

Explore this scatter interactively →