CDC45

Across TCGA pan-cancer cohorts, CDC45 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated CDC45 data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CDC45 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDC45 expression acts as an unfavorable survival marker, although some lineages such as READ and OV show a favorable association.

ACC, MESO, and KIRP are the cancer types where CDC45 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.236	0.641	<.001	171	view →
MESO	OS	Median	All	0.257	0.513	<.001	132	view →
KIRP	DFS	Median	All	0.782	0.921	<.001	118	view →
KICH	OS	Median	III,IV	0.363	0.957	<.001	92	view →
KIRC	DFS	Quartile	All	0.471	0.661	<.001	92	view →
LIHC	OS	Median	All	0.697	0.859	<.001	81	view →
PAAD	DFS	Median	All	0.198	0.376	<.001	61	view →
UVM	DFS	Quartile	III,IV	0.155	0.903	<.001	55	view →
LGG	OS	Median	All	0.727	0.894	<.001	54	view →
LUAD	OS	Median	All	0.761	0.861	<.001	42	view →
SKCM	OS	Median	All	0.276	0.414	<.001	34	view →
READ	OS	Tertile	All	1.000	0.319	.006	29	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

CDC45–ACC (DFS)

Open the ACC breakdown →