CDC45

Across TCGA patient cohorts, CDC45 mutation is significantly associated with the RNA expression of many other genes, with 1,150 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC45-associated genes across cancer lineages are RNU6-666P, MTCYBP34, and SNU13. Each is linked with CDC45 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC45-to-partner and partner-to-CDC45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-666P grouped by CDC45-low versus CDC45-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC45→partner) and Y-score (partner→CDC45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-666P →	+0.986	+6.734	<.001	<.001	3	2
COAD	MTCYBP34 →	+0.251	+5.122	<.001	.004	3	2
UCEC	SNU13 →	+0.249	+3.499	.009	.002	3	2
SKCM	BCAR1P2 →	+0.040	+2.858	<.001	.007	3	2
BLCA	RNU1-52P →	+0.084	+4.229	<.001	.006	3	2
UCEC	B3GNT8 →	-0.701	-2.087	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,150 associations by consensus.

RNU6-666P by CDC45 expression — COAD

Explore this box plot interactively →