CDC45

Across TCGA cell cohorts, CDC45 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,829 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CDC45-associated GO terms across cancer lineages are DNA-templated DNA replication, DNA recombination, and Nuclear DNA replication. Each is linked with CDC45 in more than 19 cancer types. Because this analysis shows association rather than direction, both CDC45-to-partner and partner-to-CDC45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by CDC45-low versus CDC45-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC45→partner) and Y-score (partner→CDC45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA-templated DNA replication →	+0.145	+1.580	<.001	<.001	3	20
OESOPHAGUS	DNA recombination →	+0.100	+2.154	<.001	<.001	3	20
BONE	Nuclear DNA replication →	+0.230	+1.891	<.001	<.001	3	20
BONE	Cell cycle DNA replication →	+0.219	+1.818	<.001	<.001	3	20
OVARY	Replication fork processing →	+0.104	+1.221	<.001	<.001	3	20
SOFT_TISSUE	Cellular response to cisplatin →	+0.293	+1.452	.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,829 associations by consensus.

DNA-templated DNA replication by CDC45 expression — BONE

Explore this box plot interactively →