CDC45

Across TCGA cell cohorts, CDC45 mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDC45-associated genes across cancer lineages are CCT8L2, POTEG, and OR13C3. Each is linked with CDC45 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC45-to-partner and partner-to-CDC45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT8L2 grouped by CDC45-low versus CDC45-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC45→partner) and Y-score (partner→CDC45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCT8L2 →	+0.009	+3.289	<.001	.009	3	2
URINARY_TRACT	POTEG →	+0.114	+3.807	.006	.005	3	1
LUNG_NSCLC_LUAD	OR13C3 →	+0.018	+4.887	<.001	.009	3	1
LARGE_INTESTINE	MCAT →	+0.877	+3.082	<.001	.007	3	1
LARGE_INTESTINE	MRO →	+0.207	+3.215	.006	.009	3	1
LARGE_INTESTINE	DUSP11 →	+0.434	+3.067	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

CCT8L2 by CDC45 expression — BLOOD_Leukemia

Explore this box plot interactively →