CDC42EP3

Across TCGA patient cohorts, CDC42EP3 mutation is significantly associated with the RNA expression of many other genes, with 2,433 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC42EP3-associated genes across cancer lineages are FTMT, RPL7P30, and PIGPP3. Each is linked with CDC42EP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDC42EP3-to-partner and partner-to-CDC42EP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTMT grouped by CDC42EP3-low versus CDC42EP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC42EP3→partner) and Y-score (partner→CDC42EP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FTMT →	+0.155	+1.501	<.001	.009	3	3
BRCA	RPL7P30 →	+0.090	+5.203	.004	.007	3	2
BRCA	PIGPP3 →	+0.113	+5.926	<.001	.002	3	2
BRCA	RPL36AP6 →	+0.199	+5.203	<.001	.007	3	2
COAD	CHEK2P5 →	+0.257	+4.418	<.001	.008	3	2
COAD	POMPP1 →	+0.364	+4.962	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,433 associations by consensus.

FTMT by CDC42EP3 expression — UCEC

Explore this box plot interactively →