CDC42BPG

Across TCGA pan-cancer cohorts, CDC42BPG mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CDC42BPG’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CDC42BPG mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CDC42BPG is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, LSCC, and LUAD are the cancer types where CDC42BPG tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDC42BPG mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−0.443	<.001	12	view →
LSCC	Male	All	−0.333	<.001	8	view →
LUAD	Male	III,IV	−0.432	<.001	6	view →
COAD	Male	All	+0.185	.026	2	view →
CCRCC	All	III,IV	−0.208	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CDC42BPG–HNSC

Open the HNSC breakdown →