CDC42BPG

Across TCGA pan-cancer cohorts, CDC42BPG RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CDC42BPG data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CDC42BPG RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CDC42BPG expression acts as an unfavorable survival marker, although some lineages such as KIRP and KIRC show a favorable association.

KIRP, KIRC, and UVM are the cancer types where CDC42BPG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.973	0.846	<.001	121	view →
KIRC	OS	Median	All	0.728	0.542	<.001	106	view →
UVM	DFS	Median	All	0.736	0.423	<.001	98	view →
LGG	DFS	Median	All	0.614	0.846	<.001	54	view →
SKCM	OS	Median	All	0.724	0.840	<.001	49	view →
SCLC	DFS	Median	II,III,IV	0.819	0.205	.004	30	view →
BRCA	DFS	Tertile	IV	0.370	0.873	.001	29	view →
ACC	OS	Tertile	III,IV	0.919	0.324	.013	15	view →
LUSC	DFS	Quartile	III,IV	0.379	0.935	.014	12	view →
OV	OS	Median	III,IV	0.270	0.375	.009	8	view →
THYM	DFS	Median	III,IV	0.912	0.436	.042	6	view →
BLCA	OS	Quartile	All	0.806	0.671	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CDC42BPG–KIRP (DFS)

Open the KIRP breakdown →