CDC42-IT1

Across TCGA pan-cancer cohorts, CDC42-IT1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CDC42-IT1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CDC42-IT1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CDC42-IT1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

HNSC, KICH, and ACC are the cancer types where CDC42-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.821	0.713	.002	82	view →
KICH	DFS	Tertile	III,IV	0.285	1.000	.004	51	view →
ACC	OS	Quartile	II,III,IV	0.277	0.829	<.001	44	view →
PAAD	OS	Median	All	0.581	0.409	.012	21	view →
STAD	OS	Quartile	All	0.754	0.571	.014	16	view →
PCPG	DFS	Quartile	All	0.462	0.917	.003	15	view →
LAML	DFS	Quartile	All	0.556	0.335	.017	12	view →
SKCM	DFS	Quartile	All	0.287	0.174	.006	8	view →
SARC	OS	Tertile	All	0.318	0.590	.008	8	view →
THCA	DFS	Median	IV	0.477	0.785	.022	8	view →
UCEC	DFS	Median	All	0.872	0.803	.025	8	view →
COAD	DFS	Tertile	IV	0.674	0.409	.032	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CDC42-IT1–HNSC (OS)

Open the HNSC breakdown →