CDC25C

Across TCGA patient cohorts, CDC25C mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC25C-associated genes across cancer lineages are ATM, Ku80, and PDCD4. Each is linked with CDC25C in more than 2 cancer types. Because this analysis shows association rather than direction, both CDC25C-to-partner and partner-to-CDC25C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CDC25C-low versus CDC25C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC25C→partner) and Y-score (partner→CDC25C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.654	-3.308	<.001	.009	3	3
UCEC	Ku80 →	+0.268	+1.713	.007	.027	3	2
UCEC	PDCD4 →	-0.536	-1.700	.007	.044	3	2
UCEC	Cyclin-B1 →	+0.618	+2.222	.009	.011	3	2
UCEC	EGFR_pY1068 →	-0.230	-1.700	.031	.044	3	1
UCEC	HER3_pY1289 →	+0.074	+2.341	.042	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by CDC25C expression — UCEC

Explore this box plot interactively →