CDC25C

Across TCGA pan-cancer cohorts, CDC25C RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of CDC25C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CDC25C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CDC25C is over-expressed in tumor.

HNSC, LUAD, and BLCA are the cancer types where CDC25C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDC25C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.381	<.001	12	view →
LUAD	All	IV	+3.139	<.001	11	view →
BLCA	Male	All	+2.189	<.001	11	view →
KIRP	Male	III,IV	+1.279	<.001	11	view →
KIRC	Male	IV	+1.040	<.001	11	view →
COAD	Female	II,III,IV	+1.259	<.001	10	view →
LUSC	Female	All	+2.537	<.001	9	view →
LIHC	Male	All	+1.949	<.001	9	view →
UCEC	All	II,III,IV	+2.935	<.001	8	view →
STAD	Female	All	+2.231	<.001	8	view →
BRCA	All	III,IV	+2.206	<.001	6	view →
READ	All	All	+0.841	.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

CDC25C–HNSC

Open the HNSC breakdown →