CDC20B

Across TCGA patient cohorts, CDC20B mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC20B-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and JNK_pT183_Y185. Each is linked with CDC20B in more than 2 cancer types. Because this analysis shows association rather than direction, both CDC20B-to-partner and partner-to-CDC20B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CDC20B-low versus CDC20B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC20B→partner) and Y-score (partner→CDC20B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.198	+1.904	.035	.029	3	3
SKCM	Cyclin-B1 →	+0.406	+2.807	.021	.003	3	2
UCEC	JNK_pT183_Y185 →	-0.168	-3.000	.004	<.001	3	2
UCEC	PCNA →	+0.155	+1.874	.038	.049	3	2
UCEC	Caspase-7-cleavedD198 →	+0.469	+1.926	.022	.008	3	2
UCEC	cIAP →	+0.094	+2.232	.049	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

4E-BP1 by CDC20B expression — UCEC

Explore this box plot interactively →