CDC20B

mutation — cross-omics
Cross-omicsMUTATION → RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, CDC20B mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDC20B-associated genes across cancer lineages are GP2, MS4A4A, and C16orf96. Each is linked with CDC20B in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC20B-to-partner and partner-to-CDC20B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GP2 grouped by CDC20B-low versus CDC20B-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC20B→partner) and Y-score (partner→CDC20B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BLOOD_MyelomaGP2 →+0.026+4.807<.001.00631
LARGE_INTESTINEMS4A4A →+0.174+3.000<.001.00631
LARGE_INTESTINEC16orf96 →+0.519+3.520.003.00531
OVARYARGFX →+0.035+5.196<.001.00531
LARGE_INTESTINESH3GL2 →+1.462+3.252<.001.00921
LARGE_INTESTINETKTL2 →+0.045+3.187<.001.00621
Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GP2 by CDC20B expression — BLOOD_Myeloma

Box plot of GP2 in CDC20B-low vs CDC20B-high samples in BLOOD_Myeloma.

Explore this box plot interactively →

Exploration