Across TCGA patient cohorts, CDC14C mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC14C-associated genes across cancer lineages are Di-Ras3, PCNA, and JNK2. Each is linked with CDC14C in more than 2 cancer types. Because this analysis shows association rather than direction, both CDC14C-to-partner and partner-to-CDC14C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC14C→partner) and Y-score (partner→CDC14C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.122	-1.415	.028	.046	3	3
LUSC	PCNA →	+0.366	+2.816	.001	.036	3	2
UCEC	JNK2 →	+0.185	+1.763	.012	.048	3	2
LUAD	G6PD →	+0.619	+3.169	.009	.019	3	1
LUAD	PRDX1 →	+0.412	+2.824	.002	.034	3	1
UCEC	Heregulin →	-0.096	-1.765	.037	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

CDC14C survival (RNA) · tumor vs normal (RNA) · all CDC14C data types