Across TCGA pan-cancer cohorts, CDC14C RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CDC14C’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where CDC14C RNA is repressed in tumor relative to normal tissue. In most cancer types CDC14C is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.
BRCA, THCA, and PAAD are the cancer types where CDC14C tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDC14C RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.