CDC14A

Across TCGA patient cohorts, CDC14A mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC14A-associated genes across cancer lineages are c-Kit, eIF4E, and GAPDH. Each is linked with CDC14A in more than 2 cancer types. Because this analysis shows association rather than direction, both CDC14A-to-partner and partner-to-CDC14A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by CDC14A-low versus CDC14A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC14A→partner) and Y-score (partner→CDC14A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Kit →	-0.178	-1.584	.022	.009	3	3
UCEC	eIF4E →	+0.223	+2.584	.001	<.001	3	2
UCEC	GAPDH →	+0.379	+2.000	.035	.029	3	2
UCEC	ACC1 →	+0.255	+1.750	.036	.049	3	2
UCEC	ACVRL1 →	-0.123	-1.687	.007	.040	3	2
UCEC	TFRC →	+0.354	+1.874	.046	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

c-Kit by CDC14A expression — UCEC

Explore this box plot interactively →