CDC14A

Across TCGA pan-cancer cohorts, CDC14A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CDC14A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CDC14A RNA is repressed in tumor relative to normal tissue. In most cancer types CDC14A is over-expressed in tumor, although a few such as COAD and KIRP show the opposite, repressed pattern.

COAD, KIRP, and LUAD are the cancer types where CDC14A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDC14A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.721	<.001	11	view →
KIRP	All	II,III,IV	−1.052	<.001	9	view →
LUAD	Female	III,IV	−1.342	<.001	8	view →
LUSC	Female	All	−1.243	<.001	8	view →
KIRC	Male	All	−0.462	<.001	8	view →
BRCA	Female	All	−0.815	<.001	4	view →
LIHC	All	All	+0.403	<.001	4	view →
READ	Female	All	−1.713	.001	2	view →
UCEC	All	All	−0.632	.010	2	view →
CHOL	All	All	+0.577	.002	2	view →
PRAD	All	All	+0.368	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CDC14A–COAD

Open the COAD breakdown →