CDADC1

Across TCGA patient cohorts, CDADC1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDADC1-associated genes across cancer lineages are Rad50, eIF4E, and A-Raf_pS299. Each is linked with CDADC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDADC1-to-partner and partner-to-CDADC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by CDADC1-low versus CDADC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDADC1→partner) and Y-score (partner→CDADC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.284	-3.459	.003	.005	3	2
UCEC	eIF4E →	+0.173	+2.415	.041	.003	3	1
UCEC	A-Raf_pS299 →	-0.128	-2.584	.007	.010	3	1
UCEC	ACVRL1 →	-0.159	-3.156	.003	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.166	-2.000	.014	.030	3	1
UCEC	MEK1 →	+0.387	+2.700	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Rad50 by CDADC1 expression — UCEC

Explore this box plot interactively →