CDA

Across TCGA pan-cancer cohorts, CDA mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CDA data layer compared with 29 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CDA mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CDA expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where CDA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.327	0.811	<.001	28	view →
HNSC	DFS	Tertile	All	0.785	0.532	.009	22	view →
CCRCC	OS	Median	All	0.770	0.912	.030	1	view →
PDAC	OS	Quartile	III,IV	0.494	0.979	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CDA–LUAD (OS)

Open the LUAD breakdown →