CD8B

Across TCGA patient cohorts, CD8B mutation is significantly associated with the RNA expression of many other genes, with 903 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD8B-associated genes across cancer lineages are PSMD9, ANAPC11, and KIF22. Each is linked with CD8B in more than 1 cancer types. Because this analysis shows association rather than direction, both CD8B-to-partner and partner-to-CD8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMD9 grouped by CD8B-low versus CD8B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD8B→partner) and Y-score (partner→CD8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PSMD9 →	+0.256	+1.879	.008	.004	3	2
SKCM	ANAPC11 →	+0.358	+3.820	.005	<.001	3	2
SKCM	KIF22 →	+0.337	+1.867	.004	.005	3	2
UCEC	PGP →	+0.596	+3.364	.001	.004	3	2
UCEC	CIDECP1 →	+0.545	+3.716	<.001	<.001	3	2
UCEC	VDAC1 →	+0.524	+2.743	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 903 associations by consensus.

PSMD9 by CD8B expression — SKCM

Explore this box plot interactively →