CD8B

Across TCGA pan-cancer cohorts, CD8B RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CD8B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CD8B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CD8B is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

KIRC, LUSC, and KIRP are the cancer types where CD8B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CD8B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.184	<.001	11	view →
LUSC	Male	III,IV	−2.322	.001	2	view →
KIRP	All	All	+0.554	.008	2	view →
KICH	All	All	−0.431	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CD8B–KIRC

Open the KIRC breakdown →