CD8B

Across TCGA patient cohorts, CD8B mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD8B-associated genes across cancer lineages are EGFR_pY1068, FASN, and Notch1. Each is linked with CD8B in more than 1 cancer types. Because this analysis shows association rather than direction, both CD8B-to-partner and partner-to-CD8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CD8B-low versus CD8B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD8B→partner) and Y-score (partner→CD8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.266	-2.321	.035	.035	2	2
UCEC	FASN →	+0.524	+2.321	.008	.035	3	1
UCEC	Notch1 →	+0.237	+3.013	<.001	.018	3	1
UCEC	PDCD4 →	-0.683	-2.312	.003	.034	3	1
SKCM	GSK-3_pS9 →	+0.407	+3.000	.043	.035	3	1
SKCM	IGFBP2 →	-0.533	-2.000	.020	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1068 by CD8B expression — UCEC

Explore this box plot interactively →