CD8B

Across TCGA cell cohorts, CD8B RNA expression is significantly associated with the go_rna of many other GO terms, with 536 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CD8B-associated GO terms across cancer lineages are Regulation by virus of viral protein levels in host cell, Protein K48-linked ubiquitination, and Regulation of complement activation. Each is linked with CD8B in more than 3 cancer types. Because this analysis shows association rather than direction, both CD8B-to-partner and partner-to-CD8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation by virus of viral protein levels in host cell grouped by CD8B-low versus CD8B-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CD8B→partner) and Y-score (partner→CD8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation by virus of viral protein levels in host cell →	+0.076	+0.766	.001	.002	3	4
LARGE_INTESTINE	Protein K48-linked ubiquitination →	+0.041	+1.002	.007	.005	3	3
CNS	Regulation of complement activation →	-0.128	-0.052	.003	.002	3	3
BLOOD_Leukemia	Response to gamma radiation →	+0.054	+0.302	<.001	.002	3	3
LUNG_SCLC	Regulation of microglial cell mediated cytotoxicity →	-0.137	-1.206	.005	.003	2	4
LUNG_SCLC	Chromosome separation →	+0.102	+1.053	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 536 associations by consensus.

Regulation by virus of viral protein levels in host cell by CD8B expression — LARGE_INTESTINE

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