CD8A

Across TCGA patient cohorts, CD8A mutation is significantly associated with the RNA expression of many other genes, with 630 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD8A-associated genes across cancer lineages are RPL9P15, MIR1185-2, and RNA5SP519. Each is linked with CD8A in more than 1 cancer types. Because this analysis shows association rather than direction, both CD8A-to-partner and partner-to-CD8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL9P15 grouped by CD8A-low versus CD8A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD8A→partner) and Y-score (partner→CD8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL9P15 →	+0.181	+4.990	<.001	.009	3	2
UCEC	MIR1185-2 →	+0.181	+4.010	<.001	.007	3	2
UCEC	RNA5SP519 →	+0.618	+2.813	<.001	.005	3	2
BRCA	RN7SL248P →	+0.139	+6.786	<.001	<.001	3	1
BRCA	MIR8075 →	+0.475	+6.442	<.001	.001	3	1
SKCM	MIR6826 →	+0.472	+4.295	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 630 associations by consensus.

RPL9P15 by CD8A expression — LUAD

Explore this box plot interactively →