CD81-AS1

Across TCGA pan-cancer cohorts, CD81-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CD81-AS1 data layer compared with 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CD81-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CD81-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, LUSC, and SKCM are the cancer types where CD81-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.736	0.551	<.001	75	view →
LUSC	OS	Median	III,IV	0.248	0.552	<.001	72	view →
SKCM	DFS	Quartile	All	0.676	0.509	<.001	53	view →
UCEC	DFS	Quartile	All	0.534	0.726	.001	30	view →
LUAD	DFS	Tertile	IV	0.266	1.000	.011	14	view →
LGG	DFS	Tertile	All	0.520	0.333	<.001	14	view →
CESC	DFS	Median	All	0.413	0.637	.001	12	view →
PRAD	DFS	Quartile	All	0.787	0.890	.018	10	view →
BRCA	OS	Quartile	IV	0.908	0.317	.017	9	view →
LAML	DFS	Median	All	0.447	0.678	.011	8	view →
COAD	OS	Tertile	II,III,IV	0.801	0.921	.016	6	view →
DLBC	DFS	Median	II,III,IV	0.849	0.540	.033	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CD81-AS1–HNSC (DFS)

Open the HNSC breakdown →